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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T8978 | DD1 | 3,3'-Diamino-4'-methoxyflavone,HUN85111 | Proteasome |
DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis. | |||
T13273 | UT-34 | Androgen Receptor | |
UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost... | |||
T6583 | MG-101 | ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101 | Cysteine Protease , Proteasome |
MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins. | |||
T10765 | Eragidomide | CC-90009,Cereblon modulator 1 | Apoptosis , Ligand for E3 Ligase , Molecular Glues |
Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex. | |||
T8745 | PROTAC BRAF-V600E degrader-1 | Compound 23 | Raf |
PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF. | |||
T21510 | PSI | Proteasome | |
PSI is a proteasome inhibitor. | |||
T12628 | (R)-MG-132 | (S,R,S)-(-)-MG-132,Z-Leu-D-leu-leu-al | Proteasome |
(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132. | |||
T21854 | Proteasome inhibitor IX | PS-IX,AM114 | Proteasome |
Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c... | |||
T21617 | MG-115 | Z-LL-Nva-CHO | Proteasome |
MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas... | |||
T7016 | VR23 | Apoptosis , Proteasome , Caspase | |
VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes. | |||
T6029 | ONX-0914 | ONX0914,PR-957,ONX 0914 | Proteasome , HIV Protease , Antibacterial |
ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome. | |||
T77620 | LMTK3-IN-1 | c-Met/HGFR | |
Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway. LMTK3-IN-1 has shown anticancer activity in a variety of cancer c... | |||
T12561 | Proteasome-IN-1 | Proteasome | |
Proteasome-IN-1 is an inhibitor of proteasome. | |||
T16795 | Rpn11-IN-1 | Capzimin intermediate | Others |
Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM). | |||
T81371 | Proteasome-IN-5 | Proteasome | |
Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1]. | |||
T81373 | Proteasome β2c/i-IN-1 | Proteasome | |
Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1]. | |||
T79842 | Davelizomib | Proteasome | |
Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1]. | |||
T21968 | MG-262 | ||
MG-262 is a reversible proteasome inhibitor with multiple biological activities [1] [2] [3]. | |||
T75623 | Sadopeptins A | ||
Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1]. | |||
T62255 | 20S Proteasome-IN-4 | ||
20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag... |